Internship / Job position
Postdoctoral Research Fellow - Tumour Immunology, Dublin-doctoral positionPost-doctoral position
University College Dublin (UCD) is seeking applications for a Postdoctoral Research Fellow to work on the interaction
between immune and cancer cells across different tumour models using modern cell and molecular biology methods.
For further information please see attached Job Ref. or search for ref. 016865 on Jobs - Work at UCD
Closing Date: Tuesday, 20 February 2024
Computational Biologist, Milan - Fixed Term-doctoral positionPost-doctoral position
This is a unique opportunity for bioinformaticians who are interested in elucidating the organization of human cancer with the most advanced technologies for spatial transcriptomics and genomics (already available in the group).
The lab is internationally recognized, well-funded and growing, so it should be a good fit for motivated and ambitious candidates seeking professional growth or consolidation. We offer a fixed-term job contract with competitive salary and benefits (commensurate to experience), possibility for transition to a permanent position.
Applications must include an updated CV with contact information for 2/3 references and a statement letter outlining
specific motivations to join the lab and current/future research interests. All documents should be sent by email to
immediately and proceed until the position is filled.
Phd Position - Neutrophil-driven Pulmonary disorders-doctoral positionPost-doctoral position
NOVEL REGULATION PATHWAYS OF NEUTROPHIL SERINE PROTEASE (NSP) ACTIVATION
In chronic lung diseases such as Cystic Fibrosis lung disease or Chronic Obstructive Pulmonary Disease, the lung is susceptible to destruction of lung tissue by human cells that normally participate in removing bacteria from the lung. These human cells (neutrophils) release enzymes that can degrade lung tissue and cause inflammation in the lung. In this study, we will evaluate how these enzymes are synthesised prior to their release from neutrophils which will include development of new inhibitors to regulate their activity
Neutrophil Serine Proteases (NSPs) such as Neutrophil Elastase (NE) are known to be present in the lungs of individuals with various chronic lung diseases including Cystic Fibrosis (CF) lung disease and Chronic Obstructive Pulmonary Disease (COPD). It is known that NE correlates significantly to the development of bronchiectasis in early CF and other studies have demonstrated that inhibition of another protease, cathepsin C (CatC), which is known to regulate NSP activation, results in reduced frequency of exacerbation in individuals with bronchiectasis. However, recent data from the Taggart laboratory shows that there is another level of regulation of NSP activity. The proposed project will delineate further this novel NSP processing activity and evaluate how this activity impacts neutrophil function including oxidant generation and bacterial killing. In addition, there will be a focus on measurement of protease activity assays and analysis of neutrophil gene expression. The study will be a collaboration between the Taggart laboratory in the Wellcome Wolfson Institute for Experimental Medicine, the Williams laboratory in the Patrick G Johnston Centre for Cancer Research, the Tirouvanziam laboratory in the Emory University, Atlanta, USA and the company partner ProAxsis, where the student will spend time conducting protease activity assays.
More information at: https://www.qub.ac.uk/courses/postgraduate-research/phd-opportunities/novel-regulation-pathways-of-neutrophil-serine-protease-nsp-activation.html
Post-doctoral position - Institut Curie, Paris, FR.-doctoral positionPost-doctoral position
The department of Immunology headed by Ana-Maria Lennon-Duménil is actively looking for a Post-doc motivated to work on an ambitious project in translational Immunology.
Institut Curie (http://www.institut-curie.org) is one of the most renowned European
institutions for cancer research with a strong interdisciplinary tradition. It is located in the center of Paris, in a culturally and scientifically rich environment. This position is open in the team of Tumor Immunobiology of Dr Emanuela Romano, medical director of the Center for Cancer Immunotherapy embedded in the "Immunity and Cancer” INSERM Unit 932
(https://science.institut-curie.org/research/integrated-biology/u932-immunity-and-cancer/;https://institut-curie.org/personne/emanuela-romano). The candidate will benefit from the high-level scientific environment of our Research Institute, as well as of state-of-the-art technological platforms (imaging, proteomics, genomics, flow cytometry, bioinformatics, biostatistics, sequencing facilities, etc...). Our center includes research teams in the fields of basic and translational immunology, working in a very collaborative and international environment. The selected candidate will work in close collaboration with biologists and bioinformaticians under the supervision of Dr Emanuela Romano. The open position is in line with recent developments at the interface between Immunology and Bioinformatics.
The successful candidate will be involved in immunology projects in close collaboration with biologists, bioinformaticians, and medical doctors with the aim of better understanding cell networks associated with immunotherapy outcome in breast and ovarian cancers.
Treatment combinations with anti-PD-(L)1 antibodies have significantly increased the
response rates for several patients with solid tumors. Despite these advances, the
contribution of distinct tumor microenvironments to immunotherapy response remains largely unknown. We hypothesize that by tracing the adaptation of breast cancer to (chemo)-immune checkpoint blockade through deep characterization of the tumor, immune, and stromal microenvironment (TISME) using human samples, obtained prior and on-treatment in the course of academic clinical trials, we will address this clinical need.
The candidate holds a PhD in Immunology with a solid background in Immunology, cell Biology, and Biostatistics. Good knowledge in approaches such as cell culture, in vitro experiments using primary human immune cells, flow cytometry and single-cell RNAseq analysis are required. Knowledge of multivariate statistics is not mandatory but would be
The candidate will generate and analyze the data obtained from cell culture, in vitro using primary human immune cells, flow cytometry and single-cell RNAseq from tissue samples derived from either cancer patients or normal donors. The candidate will master the literature related to the project/s and follow the developments in his/her domain of interest. The candidate is expected to have a teamwork spirit and good
communication skills, be autonomous and open to new experimental approaches.
· Experience in management and manipulation of human samples
· Experience in cell culture and in vitro experiments
· Knowledge in statistics
· Basic experience in the use of bioinformatics tools for single cell RNAseq analysis and
differential gene analysis (ex: R)
· Experience in tissue imaging (ex: multiplex IHC, IF) is appreciated by not mandatory
· Fluent written and spoken English is mandatory.
The position is open and funded for 18 months with possible extension. If you are interested, please, send your CV, a cover along with 2 letters of reference to Dr Emanuela Romano
Postdoctoral Fellow – Immunology
Postdoc position – Immunosuppressive factors in the tumor microenvironment as modulators of immunotherapy efficacy
he project will be carried out in the Tumor Stroma and Matrix Immunology (TSMI) group at the National Center for Cancer Immunotherapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital, Herlev, Denmark, a research center with a strong background in experimental and clinical cancer immunotherapy research. Many clinical immunotherapy trials are currently running at CCIT, several of which originate from our own pre-clinical research results. The TSMI group is one of five research groups at the center and is headed by Associate Professor and Lundbeck Fellow, Daniel H. Madsen. The goal of the research group is to discover molecular mechanisms by which the tumor microenvironment influences immunotherapy efficacy, and to use this knowledge for the development of new therapeutic strategies for improving immunotherapy. The TSMI group is currently studying how the extracellular matrix and different cellular components of the tumor microenvironment affect the activity of tumor-infiltrating T cells. We also focus on the role of hypoxia for immunotherapy efficacy and on the discovery of new targets for improving cancer immunotherapy. The research projects are among other things based on mouse models, 3D cell culture assays, and clinical samples from cancer patients. The TSMI group is an international group currently consisting of two postdocs, three PhD students, and two Master’s students.
Cancer immunotherapy has had a major breakthrough within the last decade with the discoveries that endogenous cytotoxic T cells possess the ability to react against cancer cells and that the blocking of immunosuppressive signals can be sufficient for obtaining extremely impressive clinical results. Still, however, many cancer patients do not respond to immunotherapy. One likely reason for this is that the local T cell response in the tumor gets suppressed by immunosuppressive factors in the tumor microenvironment.
The selected candidate will work on a project within the focus area of the TSMI group. The exact research project will be defined after discussions with the applicant, taking into consideration the interests and expertise of the applicant. The project will involve methods such as mouse cancer models, 3D cell culture assays, RNA-sequencing, flow cytometry, immunohistochemistry, co-culture assays, cytokine profiling, and FACS-isolation of specific cell populations for functional assays.
May 1st, 2024 or after agreement.
Application deadline is February 15th, 2024.
The application should include a motivated letter of application (max. 1 page), a CV (including publication list), relevant diplomas, and contact details of at least 2 references.
Postdoctoral position in T cell tumor immunology in the Lillemeier laboratory at the University of Freiburg
The goal of this postdoctoral position is to characterize these novel mechanisms in mouse tumor models in vivo to determine if they are suitable targets for future immunotherapies. The successful candidate will investigate the effects of mutant T cell signaling molecules on anti-tumor responses using novel mouse tumor models in vivo. These tumor models have been previously established by the Lillemeier group specifically for these projects. In addition, the T cell signaling mutants will be characterized through ex vivo immunological assays and multidimensional profiling of the tumor infiltrating immune cells.
The Lillemeier lab is highly collaborative with strong ties to the immunology community in Freiburg and beyond. Thus, this postdoctoral position will be an excellent fit for a team player who is interested in collaborative research. The successful candidate will use a state-of-the-art spectral flow cytometer in the Lillemeier lab, and also have access to multiple well-equipped core facilities.
Requirements: • PhD in immunology, virology, cell biology or related field. • Publication(s) in peer-reviewed journals. • Expertise in mouse work, ideally with tumor models. A license to work with animals in the EU (e.g. FELASA certificate) is preferred. • Expertise in multi-parameter flow cytometry. If required, additional training for spectral flow cytometry will be provided. • Experience with in vitro immunological assays and tissue culture. • Familiarity with RNA sequencing and/or TCR repertoire analysis will be useful, but is not required.
This full-time postdoctoral position is available immediately (or as soon as possible) for an initial term until 31st of December 2025 with possibility of extension.
Lecturer in Biomedical Sciences at Ulster University
The post holder will contribute to the teaching of our undergraduate and postgraduate programmes and undertake research in line with the research interests of the School. They will advance research and education within the School of Biomedical Sciences focusing on a key aspect relevant to the biomedical sciences and will establish a programme of research in line with University and Faculty / School objectives and emerging growth deal initiatives such as the Centre for Food and Drug Discovery on the Coleraine campus.
Postdoctoral Position at the Universidad de León
Recruitment of an Assistant Professor in Immunology at the Faculty of Pharmacy Paris-Saclay
Start date: 1st September 2024.
The assistant professor will integrate the Immunology teaching team of the Faculty of Pharmacy Paris- Saclay. He/she will take part in the teaching of fundamental immunology and clinical immunology given in the 2nd and 3rd years of the common basic training in pharmacy. He/she will also be involved in supervising tutored projects, as well as in several teaching units (of the "Biology applied to therapeutic and diagnostic innovation" and "Immunology" master programs at the University of Paris-Saclay, for which the department is responsible. The assistant professor may be required to teach in English in the immunology courses of the international "Development of Drugs and Health Products" master's program. Some of the lectures may be remote or hybrid teaching.
Teaching is provided using a variety of methods, including flipped teaching, project-based training and the use of active teaching tools (e.g. wooclap). After his/her recruitment, the assistant professor will attend formations to be trained in these methods and tools, as well as in the preparation of question banks for online examinations
Candidates must be qualified (see https://galaxie.enseignementsup-recherche.gouv.fr/antares/cnu/).
The assistant professor will join the "Immunoregulation, chemokines and viral persistence" team in the INSERM UMR996 unit, located in the Henri Moissan building (faculty of pharmacy Paris-Saclay). The team focuses on epithelial immunity and human papillomavirus (HPV) host interactions. These viruses are known to cause 5% of human cancers, but all individuals are healthy carriers of HPV in their microbiota and only a minority of infections lead to pathogenesis.
In this context, the team is characterizing the mechanisms by which HPV replication and pathogenesis are controlled within pluristratified epithelia, and the impact of these viruses on the local immune fitness, based on data from both healthy subjects and patients suffering from primary immunodeficiencies associated with exacerbated HPV pathogenesis (e.g. WHIM syndrome due to a gain of function of the CXCL12/CXCR4 chemokine/receptor axis). The focus is on epithelial immune cells, particularly dendritic cells, and their interactions with keratinocytes in the context of asymptomatic infection or HPV pathogenesis. The effects of certain candidate molecules for targeted therapies are also studied.
This work is being carried out using patient samples, three-dimensional (3D) epithelial cell cultures and original transgenic mouse models, as part of national and European collaborations funded by several programs (e.g. Marie Curie actions, Fondation pour la Recherche Médicale, Agence Nationale pour la Recherche).
The assistant professor will draw on his/her expertise to develop a project that will include one or more of the following areas:
- characterization of the interactions between keratinocytes and immune cells during HPV replication or pathogenesis
- understanding the mechanisms by which the CXCL12 axis and its receptors CXCR4 and ACKR3, or other factors, regulate epithelial immunity
He/she will be able to draw on the host team's expertise in immunology, virology and cell biology and in cutting-edge methodological approaches (e.g. 3D cultures, mass/spectral cytometry, mass imaging, RNAseq, etc.), as well as on the supportive environment of the Henri Moissan site.
The project developed by the lecturer recruited to the team will be in line with the Graduate School's flagship themes of "Health and Drug Sciences" and the interdisciplinary themes of "HEALth and THerapeutic Innovation" and "Microbes" in particular, enabling access to local calls for tenders to obtain funding for transdisciplinary projects.
Teaching & Research: