Internship / Job position

Academic Development Programme - new Assistant Professors will undertake a 5-year development programme, at the end of which they are expected to be promoted to Associate Professor. The programme consists of a variety of development opportunities and the time to reflect and develop. 

We seek a discovery scientists to contribute to advancement of research in our theme by employing innovative/emerging technologies and techniques in discovery and/or data science (e,g. Inflammation biology, immunology, cellular or molecular biology or bioinformatics)

The candidate should have an interest in the key areas of our theme (i) Acute care/trauma science (ii) critical/perioperative care (iii) Respiratory Science. Within these areas, the candidate will contribute to, and lead aspects of our work to investigate fundamental mechanisms underlying inflammatory diseases using relevant modelling strategies; ex vivo, in vivo modelling or bioinformatic approaches.

The candidate will be required to deliver teaching through a range of modalities, deliver novel discovery and translational research and contribute to administration, management and community building within the institute.

The role holder will be based in Edgbaston. The key duties and responsibilities will include but not be limited to: giving lectures and seminars and supervising undergraduate / post-graduate students, course development and innovation, taking an active part in examinations, carrying out innovative research and writing papers on topics relevant to the specialist subject area (this will include journals, books and other material), and obtaining research grant funding.

The successful applicant will have a PhD in a relevant specialist subject area, as well as postdoctoral experience. We are looking for candidates who will actively contribute to our portfolio and community, through pursuit of research that will bring new opportunities, synergies, and interdisciplinary collaboration. The successful candidate will also have a track record in teaching at a higher education institution.

Person Specification

PhD or equivalent qualification  A minimum of three years’ research experience at postdoctoral level in a relevant field to the acute care theme through technical expertise or specialty.  Proven expertise in relevant discovery or data science. Informal enquires to Dr Dhruv Parekh (email hidden; JavaScript is required) or Dr Aaron Scott (email hidden; JavaScript is required)

To download the full job description and details of this position and submit an electronic application online please click on the Apply Online button:

https://edzz.fa.em3.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_6001/job/3240/?utm_medium=jobshare

The Autoimmunity Research Team is seeking passionate and self-motivated post-doctoral candidates to embark on research endeavors focusing on the role of RNA methylation in mice models of Sjogren disease (SjD). The position is currently available and funded for 2 years, subject to renewal.

Sjögren disease (SjD) is a prototypic systemic autoimmune disease affecting 0.1% of thepopulation and characterized by the dysfunction of salivary and lacrimal glands, along with numerous systemic complications and an increased risk of lymphoma. For a long timeorphaned by treatment, there is now a revolution under way, with several phase II and phase III trials in the field.

Environment: Our team, led by Pr Xavier Mariette - within Inserm UMR 1184, CEA, Université Paris-Saclay, is dedicated to exploring the pathophysiology, epidemiology, and treatment strategies for various autoimmune conditions. Our research encompasses rheumatoid
arthritis, SjD and lymphomas associated with autoimmune diseases, among other autoimmune-related disorders. We are committed to advancing our understanding of these complex diseases, investigating the underlying mechanisms driving their progression, and identifying novel therapeutic interventions. Through multidisciplinary approaches and collaborative efforts, we aim to make significant strides in improving patient outcomes and quality of life for individuals affected by autoimmune disorders. The laboratory provides state-of-the-art facilities for cellular and molecular biology, and top-level rheumatology/immunology research and an animal facility. The host lab has a particular interest in translating its basic science discoveries into translational research.

Candidates: The applicants are expected to have a strong background in immunology and immunopathology (PhD), RNA biology and cellular biology as well as in mice work, including injections and organ recuperation. The ideal candidates should be highly motivated, curious, and enthusiastic to work in a highly collaborating team. Proven ability to identify research objectives and meet agreed deadlines, self-motivation, flexibility, and assistance to other ongoing research work is essential. Excellent written and communication skills in English are required. Bioinformatics and international training will constitute an advantage.

Application: Candidates are invited to contact Dr. Rami Bechara (email hidden; JavaScript is required) for further details.

Please send an application with the following:
- Cover letter
- Concise summary of previous research activities
- Curriculum vitae including publication list and contact details for 2-3 referees

NOVEL REGULATION PATHWAYS OF NEUTROPHIL SERINE PROTEASE (NSP) ACTIVATION

In chronic lung diseases such as Cystic Fibrosis lung disease or Chronic Obstructive Pulmonary Disease, the lung is susceptible to destruction of lung tissue by human cells that normally participate in removing bacteria from the lung. These human cells (neutrophils) release enzymes that can degrade lung tissue and cause inflammation in the lung. In this study, we will evaluate how these enzymes are synthesised prior to their release from neutrophils which will include development of new inhibitors to regulate their activity

Neutrophil Serine Proteases (NSPs) such as Neutrophil Elastase (NE) are known to be present in the lungs of individuals with various chronic lung diseases including Cystic Fibrosis (CF) lung disease and Chronic Obstructive Pulmonary Disease (COPD). It is known that NE correlates significantly to the development of bronchiectasis in early CF and other studies have demonstrated that inhibition of another protease, cathepsin C (CatC), which is known to regulate NSP activation, results in reduced frequency of exacerbation in individuals with bronchiectasis. However, recent data from the Taggart laboratory shows that there is another level of regulation of NSP activity. The proposed project will delineate further this novel NSP processing activity and evaluate how this activity impacts neutrophil function including oxidant generation and bacterial killing. In addition, there will be a focus on measurement of protease activity assays and analysis of neutrophil gene expression. The study will be a collaboration between the Taggart laboratory in the Wellcome Wolfson Institute for Experimental Medicine, the Williams laboratory in the Patrick G Johnston Centre for Cancer Research, the Tirouvanziam laboratory in the Emory University, Atlanta, USA and the company partner ProAxsis, where the student will spend time conducting protease activity assays.

More information at: https://www.qub.ac.uk/courses/postgraduate-research/phd-opportunities/novel-regulation-pathways-of-neutrophil-serine-protease-nsp-activation.html

The department of Immunology headed by Ana-Maria Lennon-Duménil is actively looking for a Post-doc motivated to work on an ambitious project in translational Immunology.
 
Institut Curie (http://www.institut-curie.org) is one of the most renowned European
institutions  for  cancer  research  with  a  strong  interdisciplinary  tradition.  It  is  located  in  the center of Paris, in a culturally and scientifically rich environment. This position is open in the team of Tumor Immunobiology of Dr Emanuela Romano, medical director of the Center for Cancer Immunotherapy embedded in the  "Immunity  and  Cancer” INSERM Unit 932
(https://science.institut-curie.org/research/integrated-biology/u932-immunity-and-cancer/;https://institut-curie.org/personne/emanuela-romano).  The  candidate  will  benefit  from  the high-level  scientific  environment  of  our  Research  Institute,  as  well  as  of  state-of-the-art technological  platforms  (imaging,  proteomics,  genomics,  flow  cytometry,  bioinformatics, biostatistics, sequencing facilities, etc...). Our center includes research teams in the fields of basic and translational immunology, working in a very collaborative and international environment.  The  selected  candidate  will  work  in  close  collaboration  with  biologists  and bioinformaticians under the supervision of Dr Emanuela Romano. The open position is in line with recent developments at the interface between Immunology and Bioinformatics. 
 
Job description:
The successful candidate will be involved in immunology projects in close collaboration with biologists, bioinformaticians, and medical doctors with the aim of better understanding cell networks associated with immunotherapy outcome in breast and ovarian cancers.
Treatment combinations with anti-PD-(L)1 antibodies have significantly increased the
response rates for several patients with solid tumors. Despite these advances, the
contribution  of  distinct  tumor  microenvironments  to  immunotherapy  response  remains largely unknown. We hypothesize that by tracing the adaptation of breast cancer to (chemo)-immune  checkpoint  blockade  through  deep  characterization  of  the  tumor,  immune,  and stromal microenvironment (TISME) using human samples, obtained prior and on-treatment in the course of academic clinical trials, we will address this clinical need. 
 
Profile:
The  candidate  holds  a  PhD  in  Immunology  with  a  solid  background  in  Immunology,  cell Biology,  and  Biostatistics.  Good  knowledge  in  approaches  such  as  cell  culture,  in  vitro experiments  using  primary  human  immune  cells,  flow  cytometry  and  single-cell  RNAseq analysis  are  required.  Knowledge  of  multivariate  statistics  is  not  mandatory  but  would  be
valuable.
 

Mission: 
The  candidate  will  generate  and  analyze  the  data  obtained  from  cell  culture,  in  vitro using  primary  human  immune  cells,  flow  cytometry  and  single-cell  RNAseq from  tissue  samples derived  from  either cancer patients or normal donors.  The  candidate will  master  the  literature  related  to  the  project/s  and  follow  the  developments  in  his/her domain of interest. The candidate is expected to have a teamwork spirit and good
communication skills, be autonomous and open to new experimental approaches.
 
Knowledge
· Experience in management and manipulation of human samples
· Experience in cell culture and in vitro experiments 
· Knowledge in statistics
· Basic experience in the use of bioinformatics tools for single cell RNAseq analysis and
differential gene analysis (ex: R)
· Experience in tissue imaging (ex: multiplex IHC, IF) is appreciated by not mandatory
· Fluent written and spoken English is mandatory. 
 
Position:
The position is open and funded for 18 months with possible extension. If you are interested, please,  send  your  CV,  a  cover  along  with  2  letters  of  reference  to  Dr  Emanuela  Romano
(email hidden; JavaScript is required)
 
 
 
 

Atomic Lab at Boston University seeks a Postdoctoral Fellow with expertise in human immunology in infectious diseases and vaccinations. The successful candidate will spearhead a project focused on the subsets of memory T cells, as a promising target for universal flu vaccine development.

Ideally, the candidate must possess a prowess for high-dimensional cytometry (CyTOF and Aurora, Cytek), cell sorting, single-cell RNA sequencing, and large-scale T cell-based assays. They will apply these approaches to design, perform, and analyze investigations that will shape our studies about vaccines inducing long-lived cellular immunity.

Responsibilities:

• Lead Immunological Research Projects: Spearhead research initiatives focusing on the identification and characterization of memory T cell subsets, employing state-of-the-art cytometry techniques and human immunology assays.
• Develop and Optimize Assays: Innovate and refine immunological assays for the comprehensive analysis of immune responses, ensuring high reliability and reproducibility of results.
• Analyze and Interpret Data: Employ advanced data analysis methods to interpret complex datasets, contributing to the understanding of vaccine efficacy and immune memory.
• Collaborate: Work closely with a multidisciplinary team of scientists, clinicians, and researchers to integrate findings and advance vaccine development strategies.
• Contribute to Scientific Community: Actively participate in the preparation and presentation of research findings at national and international conferences, and contribute to high-impact peer-reviewed journals.
• Mentor Junior Researchers: Provide guidance and support to less-experienced lab members, fostering an environment of learning and professional growth.

Qualifications:

• Education: PhD in Immunology, Infection biology, Virology, or a closely related field.
• Experience in Cytometry and Immunological Assays: Demonstrated expertise in high-dimensional flow cytometry (e.g., CyTOF), cell sorting, and human immunology assays.
• Strong Analytical Skills: Ability to analyze and interpret complex biological data, with proficiency in relevant software and statistical tools.
• Publication Record: A track record of publishing research in peer-reviewed scientific journals, showcasing the ability to conduct and communicate impactful research.
• Communication Skills: Exceptional verbal and written communication skills, essential for the dissemination of research findings and collaborative interactions.
• Leadership and Mentorship: Experience in leading research projects and mentoring junior team members, demonstrating leadership and a commitment to scientific education.

This postdoctoral position offers a unique opportunity to contribute to groundbreaking research in immunology and vaccine development, with the potential to impact public health on a global scale.

The positions can be assumed immediately. Applicants should send their CV, a list of publications with highlighted intellectual and technical contributions to each listed publication, a supporting statement encompassing a cover letter and outline how you meet each selection criterion detailed in the job description, and three letters of recommendation to Prof. Dr. Adriana Tomic.

Atomic Lab (https://atomic-lab.org/) at the National Emerging Infectious Diseases Laboratories, 620 Albany Street, Boston, MA 02118

• Conduct in vivo and in vitro experiments
• Independently plan and advance the research projects
• Collaborate with internal and external partners
• Communicate research results
• Contribute to the overall work of the group to achieve common goals. This includes discussions and strategic planning of projects within the group.
• Involvement in administrative and practical tasks required for the laboratory work to proceed optimally.

• A PhD within the field of cancer biology/immunology
• Experience with relevant techniques and, preferably, with in vivo research with mice
• Fluency in English

Start date: 1st September 2024.

TEACHING :

The assistant professor will integrate the Immunology teaching team of the Faculty of Pharmacy Paris- Saclay. He/she will take part in the teaching of fundamental immunology and clinical immunology given in the 2nd and 3rd years of the common basic training in pharmacy. He/she will also be involved in supervising tutored projects, as well as in several teaching units (of the "Biology applied to therapeutic and diagnostic innovation" and "Immunology" master programs at the University of Paris-Saclay, for which the department is responsible. The assistant professor may be required to teach in English in the immunology courses of the international "Development of Drugs and Health Products" master's program. Some of the lectures may be remote or hybrid teaching.

Teaching is provided using a variety of methods, including flipped teaching, project-based training and the use of active teaching tools (e.g. wooclap). After his/her recruitment, the assistant professor will attend formations to be trained in these methods and tools, as well as in the preparation of question banks for online examinations

Candidates must be qualified (see https://galaxie.enseignementsup-recherche.gouv.fr/antares/cnu/).

RESEARCH :

The assistant professor will join the "Immunoregulation, chemokines and viral persistence" team in the INSERM UMR996 unit, located in the Henri Moissan building (faculty of pharmacy Paris-Saclay). The team focuses on epithelial immunity and human papillomavirus (HPV) host interactions. These viruses are known to cause 5% of human cancers, but all individuals are healthy carriers of HPV in their microbiota and only a minority of infections lead to pathogenesis.

In this context, the team is characterizing the mechanisms by which HPV replication and pathogenesis are controlled within pluristratified epithelia, and the impact of these viruses on the local immune fitness, based on data from both healthy subjects and patients suffering from primary immunodeficiencies associated with exacerbated HPV pathogenesis (e.g. WHIM syndrome due to a gain of function of the CXCL12/CXCR4 chemokine/receptor axis). The focus is on epithelial immune cells, particularly dendritic cells, and their interactions with keratinocytes in the context of asymptomatic infection or HPV pathogenesis. The effects of certain candidate molecules for targeted therapies are also studied.

This work is being carried out using patient samples, three-dimensional (3D) epithelial cell cultures and original transgenic mouse models, as part of national and European collaborations funded by several programs (e.g. Marie Curie actions, Fondation pour la Recherche Médicale, Agence Nationale pour la Recherche).

The assistant professor will draw on his/her expertise to develop a project that will include one or more of the following areas:

- characterization of the interactions between keratinocytes and immune cells during HPV replication or pathogenesis

- understanding the mechanisms by which the CXCL12 axis and its receptors CXCR4 and ACKR3, or other factors, regulate epithelial immunity

He/she will be able to draw on the host team's expertise in immunology, virology and cell biology and in cutting-edge methodological approaches (e.g. 3D cultures, mass/spectral cytometry, mass imaging, RNAseq, etc.), as well as on the supportive environment of the Henri Moissan site.

The project developed by the lecturer recruited to the team will be in line with the Graduate School's flagship themes of "Health and Drug Sciences" and the interdisciplinary themes of "HEALth and THerapeutic Innovation" and "Microbes" in particular, enabling access to local calls for tenders to obtain funding for transdisciplinary projects.

CONTACT :

Teaching & Research:

Pr. Géraldine Schlecht